5-Phosphoribose 1-diphosphate biosynthesis
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
AMPK inhibits chREBP transcriptional activation activity
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
ARL13B-mediated ciliary trafficking of INPP5E
AUF1 (hnRNP D0) binds and destabilizes mRNA
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Acetylcholine Neurotransmitter Release Cycle
Acetylcholine binding and downstream events
Acetylcholine regulates insulin secretion
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NTRK2 signals through FRS2 and FRS3
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation and oligomerization of BAK protein
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Activation of ATR in response to replication stress
Activation of BAD and translocation to mitochondria
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
Activation of Ca-permeable Kainate Receptor
Activation of G protein gated Potassium channels
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
Activation of NIMA Kinases NEK9, NEK6, NEK7
Activation of NMDA receptors and postsynaptic events
Activation of NOXA and translocation to mitochondria
Activation of Na-permeable kainate receptors
Activation of caspases through apoptosome-mediated cleavage
Activation of kainate receptors upon glutamate binding
Activation of the AP-1 family of transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Activation of the phototransduction cascade
Activation of the pre-replicative complex
Activation, myristolyation of BID and translocation to mitochondria
Activation, translocation and oligomerization of BAX
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
Advanced glycosylation endproduct receptor signaling
Aerobic respiration and respiratory electron transport
Alpha-protein kinase 1 signaling pathway
Amino acid transport across the plasma membrane
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Anchoring of the basal body to the plasma membrane
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen processing: Ub, ATP-independent proteasomal degradation
Antigen processing: Ubiquitination & Proteasome degradation
Antimicrobial mechanism of IFN-stimulated genes
Apoptotic cleavage of cell adhesion proteins
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
Assembly of active LPL and LIPC lipase complexes
Assembly of collagen fibrils and other multimeric structures
Assembly of the ORC complex at the origin of replication
Association of TriC/CCT with target proteins during biosynthesis
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Autodegradation of the E3 ubiquitin ligase COP1
Axonal growth inhibition (RHOA activation)
B-WICH complex positively regulates rRNA expression
BBSome-mediated cargo-targeting to cilium
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Beta oxidation of butanoyl-CoA to acetyl-CoA
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Beta-oxidation of very long chain fatty acids
Binding and Uptake of Ligands by Scavenger Receptors
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Biosynthesis of DHA-derived sulfido conjugates
Biosynthesis of DPAn-3-derived 13-series resolvins
Biosynthesis of DPAn-3-derived protectins and resolvins
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Biosynthesis of specialized proresolving mediators (SPMs)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
CDC6 association with the ORC:origin complex
CDK-mediated phosphorylation and removal of Cdc6
CLEC7A (Dectin-1) induces NFAT activation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CaMK IV-mediated phosphorylation of CREB
Cargo recognition for clathrin-mediated endocytosis
Cargo trafficking to the periciliary membrane
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Caspase-mediated cleavage of cytoskeletal proteins
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Cell death signalling via NRAGE, NRIF and NADE
Cell surface interactions at the vascular wall
Cellular response to mitochondrial stress
Cellular responses to mechanical stimuli
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)
Cholesterol biosynthesis via desmosterol (Bloch pathway)
Chondroitin sulfate/dermatan sulfate metabolism
Class C/3 (Metabotropic glutamate/pheromone receptors)
Class I MHC mediated antigen processing & presentation
Class I peroxisomal membrane protein import
Classical antibody-mediated complement activation
Cobalamin (Cbl, vitamin B12) transport and metabolism
Collagen biosynthesis and modifying enzymes
Condensation of Prometaphase Chromosomes
Conjugation of phenylacetate with glutamine
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Cross-presentation of particulate exogenous antigens (phagosomes)
Cross-presentation of soluble exogenous antigens (endosomes)
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
Cytochrome P450 - arranged by substrate type
Cytochrome c-mediated apoptotic response
Cytosolic sensors of pathogen-associated DNA
Cytosolic sulfonation of small molecules
DDX58/IFIH1-mediated induction of interferon-alpha/beta
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
DNA Damage/Telomere Stress Induced Senescence
Deactivation of the beta-catenin transactivating complex
Dectin-1 mediated noncanonical NF-kB signaling
Degradation of beta-catenin by the destruction complex
Degradation of cysteine and homocysteine
Deposition of new CENPA-containing nucleosomes at the centromere
Detoxification of Reactive Oxygen Species
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Displacement of DNA glycosylase by APEX1
Dopamine clearance from the synaptic cleft
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of TGF-beta receptor signaling
Downstream signaling events of B Cell Receptor (BCR)
Drug-mediated inhibition of CDK4/CDK6 activity
Drug-mediated inhibition of ERBB2 signaling
Drug-mediated inhibition of MET activation
E2F mediated regulation of DNA replication
E3 ubiquitin ligases ubiquitinate target proteins
EGFR interacts with phospholipase C-gamma
EGR2 and SOX10-mediated initiation of Schwann cell myelination
EML4 and NUDC in mitotic spindle formation
Electric Transmission Across Gap Junctions
Electron transport from NADPH to Ferredoxin
Endosomal Sorting Complex Required For Transport (ESCRT)
Energy dependent regulation of mTOR by LKB1-AMPK
Enzymatic degradation of Dopamine by monoamine oxidase
Enzymatic degradation of dopamine by COMT
Epigenetic regulation by WDR5-containing histone modifying complexes
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
Epigenetic regulation of gene expression
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Establishment of Sister Chromatid Cohesion
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-stimulated signaling through PRKCZ
Events associated with phagocytolytic activity of PMN cells
Expression and Processing of Neurotrophins
Extrinsic Pathway of Fibrin Clot Formation
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
FGFR1c and Klotho ligand binding and activation
FLT3 signaling through SRC family kinases
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Fcgamma receptor (FCGR) dependent phagocytosis
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Formation of ATP by chemiosmotic coupling
Formation of Fibrin Clot (Clotting Cascade)
Formation of RNA Pol II elongation complex
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Formation of TC-NER Pre-Incision Complex
Formation of WDR5-containing histone-modifying complexes
Formation of a pool of free 40S subunits
Formation of editosomes by ADAR proteins
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Formation of the Early Elongation Complex
Formation of the active cofactor, UDP-glucuronate
Formation of the beta-catenin:TCF transactivating complex
Formation of the canonical BAF (cBAF) complex
Formation of the dystrophin-glycoprotein complex (DGC)
Formation of the embryonic stem cell BAF (esBAF) complex
Formation of the non-canonical BAF (ncBAF) complex
Formation of the polybromo-BAF (pBAF) complex
Formation of the ternary complex, and subsequently, the 43S complex
Free fatty acids regulate insulin secretion
G beta:gamma signalling through PI3Kgamma
G beta:gamma signalling through PLC beta
GABA synthesis, release, reuptake and degradation
GLI3 is processed to GLI3R by the proteasome
GRB2:SOS provides linkage to MAPK signaling for Integrins
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
GTP hydrolysis and joining of the 60S ribosomal subunit
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Gamma-carboxylation of protein precursors
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Gap-filling DNA repair synthesis and ligation in GG-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Gastrin-CREB signalling pathway via PKC and MAPK
Generation of second messenger molecules
Global Genome Nucleotide Excision Repair (GG-NER)
Glucagon signaling in metabolic regulation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glutamate Neurotransmitter Release Cycle
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Glycosaminoglycan-protein linkage region biosynthesis
Glyoxylate metabolism and glycine degradation
Golgi Cisternae Pericentriolar Stack Reorganization
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
HDR through Single Strand Annealing (SSA)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Heparan sulfate/heparin (HS-GAG) metabolism
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Homologous DNA Pairing and Strand Exchange
Hydroxycarboxylic acid-binding receptors
IKK complex recruitment mediated by RIP1
IL-6-type cytokine receptor ligand interactions
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Inactivation of APC/C via direct inhibition of the APC/C complex
Inactivation, recovery and regulation of the phototransduction cascade
Incretin synthesis, secretion, and inactivation
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Inhibition of DNA recombination at telomere
Inhibition of TSC complex formation by PKB
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Initiation of Nuclear Envelope (NE) Reformation
Inorganic anion exchange by SLC26 transporters
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insulin effects increased synthesis of Xylulose-5-Phosphate
Interaction With Cumulus Cells And The Zona Pellucida
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Interconversion of nucleotide di- and triphosphates
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-4 and Interleukin-13 signaling
Intra-Golgi and retrograde Golgi-to-ER traffic
Intracellular metabolism of fatty acids regulates insulin secretion
Intracellular signaling by second messengers
Intrinsic Pathway of Fibrin Clot Formation
Ion influx/efflux at host-pathogen interface
Ionotropic activity of kainate receptors
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
KSRP (KHSRP) binds and destabilizes mRNA
L13a-mediated translational silencing of Ceruloplasmin expression
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Loss of proteins required for interphase microtubule organization from the centrosome
MAP3K8 (TPL2)-dependent MAPK1/3 activation
MAPK targets/ Nuclear events mediated by MAP kinases
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Major pathway of rRNA processing in the nucleolus and cytosol
Maturation of TCA enzymes and regulation of TCA cycle
Metabolism of Angiotensinogen to Angiotensins
Metabolism of amino acids and derivatives
Metabolism of carbohydrates and carbohydrate derivatives
Metabolism of ingested MeSeO2H into MeSeH
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Metabolism of nitric oxide: NOS3 activation and regulation
Metabolism of water-soluble vitamins and cofactors
Metal sequestration by antimicrobial proteins
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Miscellaneous transport and binding events
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mitochondrial iron-sulfur cluster biogenesis
Mitochondrial ribosome-associated quality control
Mitochondrial unfolded protein response (UPRmt)
Modulation of host responses by IFN-stimulated genes
Molecules associated with elastic fibres
MyD88 cascade initiated on plasma membrane
MyD88 dependent cascade initiated on endosome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
N-glycan antennae elongation in the medial/trans-Golgi
N-glycan trimming and elongation in the cis-Golgi
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
NFE2L2 regulating anti-oxidant/detoxification enzymes
NOTCH4 Activation and Transmission of Signal to the Nucleus
NPAS4 regulates expression of target genes
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NRIF signals cell death from the nucleus
Negative Regulation of CDH1 Gene Transcription
Negative epigenetic regulation of rRNA expression
Negative feedback regulation of MAPK pathway
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of the PI3K/AKT network
Negative regulators of DDX58/IFIH1 signaling
Neurophilin interactions with VEGF and VEGFR
Neurotransmitter receptors and postsynaptic signal transmission
Neurotransmitter uptake and metabolism In glial cells
Nitric oxide stimulates guanylate cyclase
NoRC negatively regulates rRNA expression
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Norepinephrine Neurotransmitter Release Cycle
Nuclear Events (kinase and transcription factor activation)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
O-glycosylation of TSR domain-containing proteins
OADH complex synthesizes glutaryl-CoA from 2-OA
OGDH complex synthesizes succinyl-CoA from 2-OG
Oligomerization of connexins into connexons
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Organic anion transport by SLC22 transporters
Organic anion transport by SLC5/17/25 transporters
Organic anion transport by SLCO transporters
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
PCNA-Dependent Long Patch Base Excision Repair
PD-L1(CD274) glycosylation and translocation to plasma membrane
PDH complex synthesizes acetyl-CoA from PYR
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
PI and PC transport between ER and Golgi membranes
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
POLB-Dependent Long Patch Base Excision Repair
PTK6 Regulates Proteins Involved in RNA Processing
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Phase 1 - inactivation of fast Na+ channels
Phase I - Functionalization of compounds
Phosphate bond hydrolysis by NTPDase proteins
Phosphate bond hydrolysis by NUDT proteins
Phosphorylation of CD3 and TCR zeta chains
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Plasma lipoprotein assembly, remodeling, and clearance
Platelet activation, signaling and aggregation
Polymerase switching on the C-strand of the telomere
Positive epigenetic regulation of rRNA expression
Post-transcriptional silencing by small RNAs
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein phosphorylation
Postmitotic nuclear pore complex (NPC) reformation
Postsynaptic nicotinic acetylcholine receptors
Presynaptic depolarization and calcium channel opening
Presynaptic function of Kainate receptors
Presynaptic nicotinic acetylcholine receptors
Presynaptic phase of homologous DNA pairing and strand exchange
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of DNA double-strand break ends
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
Prostacyclin signalling through prostacyclin receptor
Protein-protein interactions at synapses
Proton-coupled monocarboxylate transport
Proton-coupled neutral amino acid transporters
Purine ribonucleoside monophosphate biosynthesis
RHO GTPases Activate Rhotekin and Rhophilins
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Termination
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Termination
RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA polymerase II transcribes snRNA genes
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX1 regulates transcription of genes involved in interleukin signaling
RUNX2 regulates osteoblast differentiation
RUNX3 regulates YAP1-mediated transcription
Reactions specific to the complex N-glycan synthesis pathway
Reactions specific to the hybrid N-glycan synthesis pathway
Receptor-type tyrosine-protein phosphatases
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Recognition of DNA damage by PCNA-containing replication complex
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Recruitment of NuMA to mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Regulation of APC/C activators between G1/S and early anaphase
Regulation of CDH1 Expression and Function
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Regulation of CDH11 Expression and Function
Regulation of Expression and Function of Type I Classical Cadherins
Regulation of Expression and Function of Type II Classical Cadherins
Regulation of FOXO transcriptional activity by acetylation
Regulation of Glucokinase by Glucokinase Regulatory Protein
Regulation of HMOX1 expression and activity
Regulation of HSF1-mediated heat shock response
Regulation of Homotypic Cell-Cell Adhesion
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Regulation of MECP2 expression and activity
Regulation of MITF-M-dependent genes involved in apoptosis
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Regulation of MITF-M-dependent genes involved in pigmentation
Regulation of PD-L1(CD274) Post-translational modification
Regulation of PD-L1(CD274) transcription
Regulation of PLK1 Activity at G2/M Transition
Regulation of PTEN stability and activity
Regulation of RUNX1 Expression and Activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of T cell activation by CD28 family
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Regulation of TP53 Activity through Methylation
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Expression and Degradation
Regulation of actin dynamics for phagocytic cup formation
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of expression of SLITs and ROBOs
Regulation of gene expression by Hypoxia-inducible Factor
Regulation of gene expression in beta cells
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Regulation of innate immune responses to cytosolic DNA
Regulation of lipid metabolism by PPARalpha
Regulation of localization of FOXO transcription factors
Regulation of mRNA stability by proteins that bind AU-rich elements
Regulation of ornithine decarboxylase (ODC)
Regulation of pyruvate dehydrogenase (PDH) complex
Release of Hh-Np from the secreting cell
Release of apoptotic factors from the mitochondria
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Removal of the Flap Intermediate from the C-strand
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Resolution of AP sites via the single-nucleotide replacement pathway
Resolution of D-loop Structures through Holliday Junction Intermediates
Response of endothelial cells to shear stress
Response to elevated platelet cytosolic Ca2+
Retrograde transport at the Trans-Golgi-Network
Reversal of alkylation damage by DNA dioxygenases
Rhesus glycoproteins mediate ammonium transport
Ribosomal scanning and start codon recognition
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Role of LAT2/NTAL/LAB on calcium mobilization
SCF(Skp2)-mediated degradation of p27/p21
SCF-beta-TrCP mediated degradation of Emi1
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SIRT1 negatively regulates rRNA expression
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
SLBP independent Processing of Histone Pre-mRNAs
SLC-mediated transport of inorganic anions
SLC-mediated transport of neurotransmitters
SLC-mediated transport of organic anions
SLC-mediated transport of organic cations
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SPOP-mediated proteasomal degradation of PD-L1(CD274)
SRP-dependent cotranslational protein targeting to membrane
STAT3 nuclear events downstream of ALK signaling
STING mediated induction of host immune responses
SUMO E3 ligases SUMOylate target proteins
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMOylation of chromatin organization proteins
SUMOylation of nuclear envelope proteins
SUMOylation of ubiquitinylation proteins
Sealing of the nuclear envelope (NE) by ESCRT-III
Sema4D induced cell migration and growth-cone collapse
Sema4D mediated inhibition of cell attachment and migration
Senescence-Associated Secretory Phenotype (SASP)
Sensory perception of sweet, bitter, and umami (glutamate) taste
Serotonin Neurotransmitter Release Cycle
Serotonin clearance from the synaptic cleft
Signal regulatory protein family interactions
Signaling by Non-Receptor Tyrosine Kinases
Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Small interfering RNA (siRNA) biogenesis
Sodium-coupled sulphate, di- and tri-carboxylate transporters
Specification of the neural plate border
Strand-asynchronous mitochondrial DNA replication
Switching of origins to a post-replicative state
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Synthesis of 12-eicosatetraenoic acid derivatives
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Synthesis of PIPs at the plasma membrane
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of glycosylphosphatidylinositol (GPI)
Synthesis of pyrophosphates in the cytosol
Synthesis of substrates in N-glycan biosythesis
Synthesis of very long-chain fatty acyl-CoAs
Synthesis, secretion, and deacylation of Ghrelin
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
TAK1-dependent IKK and NF-kappa-B activation
TCF dependent signaling in response to WNT
TFAP2 (AP-2) family regulates transcription of cell cycle factors
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TICAM1-dependent activation of IRF3/IRF7
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFR1-induced NF-kappa-B signaling pathway
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Cell Cycle Genes
TP53 Regulates Transcription of Cell Death Genes
TP53 Regulates Transcription of DNA Repair Genes
TP53 Regulates Transcription of Death Receptors and Ligands
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
TRAF6-mediated induction of TAK1 complex within TLR4 complex
TWIK-related alkaline pH activated K+ channel (TALK)
TWIK-related spinal cord K+ channel (TRESK)
TWIK-releated acid-sensitive K+ channel (TASK)
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
Tandem pore domain halothane-inhibited K+ channel (THIK)
Telomere C-strand (Lagging Strand) Synthesis
Termination of translesion DNA synthesis
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
The canonical retinoid cycle in rods (twilight vision)
The retinoid cycle in cones (daylight vision)
The role of GTSE1 in G2/M progression after G2 checkpoint
Thrombin signalling through proteinase activated receptors (PARs)
Thromboxane signalling through TP receptor
Trafficking and processing of endosomal TLR
Trafficking of GluR2-containing AMPA receptors
Trafficking of myristoylated proteins to the cilium
Transcription from mitochondrial promoters
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Transcriptional activation of cell cycle inhibitor p21
Transcriptional activation of mitochondrial biogenesis
Transcriptional activation of p53 responsive genes
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Transcriptional and post-translational regulation of MITF-M expression and activity
Transcriptional regulation by small RNAs
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Transcriptional regulation of granulopoiesis
Transcriptional regulation of white adipocyte differentiation
Transfer of LPS from LBP carrier to CD14
Translation initiation complex formation
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
Translocation of ZAP-70 to Immunological synapse
Transport of Mature Transcript to Cytoplasm
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Transport of Mature mRNAs Derived from Intronless Transcripts
Transport of connexons to the plasma membrane
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Transport of glycerol from adipocytes to the liver by Aquaporins
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Transport of the SLBP Dependant Mature mRNA
Transport of the SLBP independent Mature mRNA
Transport of vitamins, nucleosides, and related molecules
Transport to the Golgi and subsequent modification
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
Unblocking of NMDA receptors, glutamate binding and activation
Uptake of dietary cobalamins into enterocytes
VEGF binds to VEGFR leading to receptor dimerization
Vasopressin regulates renal water homeostasis via Aquaporins
Vitamin B6 activation to pyridoxal phosphate
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
YAP1- and WWTR1 (TAZ)-stimulated gene expression
ZBP1(DAI) mediated induction of type I IFNs
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Zinc efflux and compartmentalization by the SLC30 family
Zinc influx into cells by the SLC39 gene family
Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
activated TAK1 mediates p38 MAPK activation
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
mitochondrial fatty acid beta-oxidation of saturated fatty acids
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
p130Cas linkage to MAPK signaling for integrins
p53-Dependent G1/S DNA damage checkpoint
p53-Independent G1/S DNA Damage Checkpoint
rRNA processing in the nucleus and cytosol
tRNA modification in the nucleus and cytosol
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Assembly and cell surface presentation of NMDA receptors
NOTCH2 Activation and Transmission of Signal to the Nucleus
PKA-mediated phosphorylation of key metabolic factors
Regulation of commissural axon pathfinding by SLIT and ROBO
Carboxyterminal post-translational modifications of tubulin
Formyl peptide receptors bind formyl peptides and many other ligands
Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'
Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'
Activation of RAC1:GTP by FZ:DSH complex
Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY
Adaptor protein complex binds to TL receptor at the plasma membrane
Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'
Catalytic processing of the nuclear factor, REL
DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
Degradation of NF-kappa-B inhibitor, CACT
Dephosphorylation by PTP61F phosphatases
Formation and asymmetric localisation of transmembrane complexes
Formation and transport of the N-HH ligand
Formation of the PGN:PGRP-LC/LE receptor 'signalling complex'
Formation of the activated STAT92E dimer and transport to the nucleus
Formation of the activated receptor complex
Formation of the cytosolic BSK 'scaffolding complex'
Formation of the nuclear AP-1 transcription factor 'scaffolding complex'
Formation of the trans-membrane 'signalling complex'
Homo-/heterophilic binding of transmembrane components
N-HH ligand bound to PTC receptor complex
N-HH ligand not bound to PTC receptor complex
Negative feedback loop regulates asymmetric localisation
PLL kinase binds to TUB in the TL receptor 'signalling complex'
Peptidoglycan bound PGRP-LC/LE oligomerises
Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE
Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
Phosphorylated REL is cleaved by and dissociates from DREDD
Phosphorylation-dependent inhibition of YKI
Phosphorylation-independent inhibition of YKI
REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol
Transcription activation by CLK:CYC and repression by VRI
Transcription repression by PER and activation by PDP1
Transcriptional activtion and repression of REL-68 target genes
Transcriptional activtion by AP-1 transcription factor
Transcriptional activtion by phosphorylated DL/DIF dimer
Transcriptional repression by nuclear factors
Ubiquitination and degradation of phosphorylated ARM
Ubiquitination and proteolysis of phosphorylated CI
ATM mediated phosphorylation of repair proteins
ATM mediated response to DNA double-strand break
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation
Activated TAK1 mediates p38 MAP kinase phosphorylation
Anaphylatoxins initiate inflammatory responses
Assembly of telomerase and telomere extension
Base Excision Repair, AP site formation by depyrimidination
Caspase-8 and -10 mediated induction of NF-kB
Chk1-controlled and DNA-damage induced centrosome duplication
Creation of alternative pathway C3 convertase
DNA damage recognition in global genomic repair
Formation of membrane attack complex (MAC)
Formation of membrane-bound convertase C3
Homologous DNA pairing and strand exchange
Homologous recombination repair (HRR) of replication-independent double-strand breaks
Homologous recombination repair of replication-dependent double-strand breaks
IKK related kinases bound to dsRNA:TLR3:TICAM1 activate IRF3
Lectin-mediated initiation of complement cascade
MyD88-dependent cascade initiated on endosome membrane
MyD88:TIRAP-dependent cascade initiated on plasma membrane
NFkB and MAPK activation mediated by TRAF6
NFkB activation mediated by RIP1 complexed with activated TLR3
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
NOTCH3 Activation and Transmission of Signal to the Nucleus
Pyrimidine metabolism: de novo synthesis of UMP
RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases
RLR (RIG-like receptor) mediated induction of IFN alpha/beta
Recruitment of repair and signaling proteins to double-strand breaks
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
TRAF6 mediated induction of proinflammatory cytokines
Translesion synthesis by DNA polymerases bypassing lesion on DNA template
Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK
Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1
3-Methylcrotonyl-CoA carboxylase deficiency
3-hydroxyisobutyryl-CoA hydrolase deficiency
ADORA2B mediated anti-inflammatory cytokines production
ALKBH2 mediated reversal of alkylation damage
ALKBH3 mediated reversal of alkylation damage
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
APOBEC3G mediated resistance to HIV-1 infection
ASL variants cause argininosuccinate aciduria
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
AXIN missense mutants destabilize the destruction complex
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
Aberrant regulation of mitotic cell cycle due to RB1 defects
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
Abortive elongation of HIV-1 transcript in the absence of Tat
Acetylcholine inhibits contraction of outer hair cells
Action of antimicrobials and antimicrobial resistance
Activation of HOX genes during differentiation
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Activation of PUMA and translocation to mitochondria
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activation of gene expression by SREBF (SREBP)
Alkylating DNA damage induced by chemotherapeutic drugs
Alternative Lengthening of Telomeres (ALT)
Anti-inflammatory response favouring Leishmania parasite infection
Antimicrobial action and antimicrobial resistance in Mtb
Assembly and Release of Dengue Virus Virions
Assembly and release of respiratory syncytial virus (RSV) virions
Assembly of Viral Components at the Budding Site
Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)
Attachment of bacteria to epithelial cells
Autointegration results in viral DNA circles
BMAL1:CLOCK,NPAS2 activates circadian expression
Binding of TCF/LEF:CTNNB1 to target gene promoters
Biosynthesis of A2E, implicated in retinal degradation
Branched-chain ketoacid dehydrogenase kinase deficiency
CD163 mediating an anti-inflammatory response
CDH11 homotypic and heterotypic interactions
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
Cell recruitment (pro-inflammatory response)
ChREBP activates metabolic gene expression
Chromatin modifications during the maternal to zygotic transition (MZT)
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Constitutive Signaling by AKT1 E17K in Cancer
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Constitutive Signaling by Overexpressed ERBB2
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Defective ABCB4 causes PFIC3, ICP3 and GBD1
Defective ABCC8 can cause hypo- and hyper-glycemias
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome
Defective ABCG8 causes GBD4 and sitosterolemia
Defective ADA disrupts (deoxy)adenosine deamination
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective B4GALT7 causes EDS, progeroid type
Defective BTD causes biotidinase deficiency
Defective Base Excision Repair Associated with MUTYH
Defective Base Excision Repair Associated with NEIL1
Defective Base Excision Repair Associated with NEIL3
Defective Base Excision Repair Associated with NTHL1
Defective Base Excision Repair Associated with OGG1
Defective CHST14 causes EDS, musculocontractural type
Defective CP causes aceruloplasminemia (ACERULOP)
Defective CYP11B2 causes CMO-1 deficiency
Defective DNA double strand break response due to BARD1 loss of function
Defective DNA double strand break response due to BRCA1 loss of function
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective F8 accelerates dissociation of the A2 domain
Defective F8 binding to the cell membrane
Defective F8 binding to von Willebrand factor
Defective F9 variant does not activate FX
Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)
Defective GGT1 in aflatoxin detoxification causes GLUTH
Defective GNE causes sialuria, NK and IBM2
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Defective HEXA causes GM2G1 (Hyaluronan metabolism)
Defective HEXB causes GM2G2 (Hyaluronan metabolism)
Defective HK1 causes hexokinase deficiency (HK deficiency)
Defective HLCS causes multiple carboxylase deficiency
Defective HPRT1 disrupts guanine and hypoxanthine salvage
Defective Inhibition of DNA Recombination at Telomere
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
Defective Intrinsic Pathway for Apoptosis
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Defective LARGE causes MDDGA6 and MDDGB6
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH3
Defective Mismatch Repair Associated With MSH6
Defective Mismatch Repair Associated With PMS2
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2
Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)
Defective RIPK1-mediated regulated necrosis
Defective SERPING1 causes hereditary angioedema
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)
Defective SLC12A1 causes Bartter syndrome 1 (BS1)
Defective SLC12A3 causes Gitelman syndrome (GS)
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
Defective SLC17A5 causes Salla disease (SD) and ISSD
Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Defective SLC1A3 causes episodic ataxia 6 (EA6)
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)
Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)
Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)
Defective SLC26A2 causes chondrodysplasias
Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
Defective SLC26A4 causes Pendred syndrome (PDS)
Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)
Defective SLC2A10 causes arterial tortuosity syndrome (ATS)
Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)
Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)
Defective SLC33A1 causes spastic paraplegia 42 (SPG42)
Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)
Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)
Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)
Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)
Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)
Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)
Defective SLC3A1 causes cystinuria (CSNU)
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)
Defective SLC5A2 causes renal glucosuria (GLYS1)
Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)
Defective SLC6A19 causes Hartnup disorder (HND)
Defective SLC6A2 causes orthostatic intolerance (OI)
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)
Defective SLC7A7 causes lysinuric protein intolerance (LPI)
Defective SLC7A9 causes cystinuria (CSNU)
Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH)
Defective SLC9A9 causes autism 16 (AUTS16)
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
Defective SRD5A3 causes SRD5A3-CDG, KHRZ
Defective ST3GAL3 causes MCT12 and EIEE15
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Defective UGT1A1 causes hyperbilirubinemia
Defective UGT1A4 causes hyperbilirubinemia
Defective VWF binding to collagen type I
Defective VWF cleavage by ADAMTS13 variant
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective binding of VWF variant to GPIb:IX:V
Defective cofactor function of FVIIIa variant
Defective factor IX causes thrombophilia
Defective factor VIII causes hemophilia A
Defective factor XII causes hereditary angioedema
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective homologous recombination repair (HRR) due to BRCA2 loss of function
Defective homologous recombination repair (HRR) due to PALB2 loss of function
Defective pro-SFTPB causes SMDP1 and RDS
Defective pro-SFTPC causes SMDP2 and RDS
Defective regulation of TLR7 by endogenous ligand
Defective translocation of RB1 mutants to the nucleus
Defective visual phototransduction due to ABCA4 loss of function
Defective visual phototransduction due to LRAT loss of function
Defective visual phototransduction due to OPN1LW loss of function
Defective visual phototransduction due to OPN1MW loss of function
Defective visual phototransduction due to OPN1SW loss of function
Defective visual phototransduction due to RDH12 loss of function
Defective visual phototransduction due to RDH5 loss of function
Defective visual phototransduction due to STRA6 loss of function
Defects in vitamin and cofactor metabolism
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
Defects of platelet adhesion to exposed collagen
Deletions in the AMER1 gene destabilize the destruction complex
Deletions in the AXIN1 gene destabilize the destruction complex
Dengue Virus Genome Translation and Replication
Dengue virus activates/modulates innate and adaptive immune responses
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Developmental Cell Lineages of the Exocrine Pancreas
Developmental Cell Lineages of the Integumentary System
Developmental Lineage of Mammary Gland Alveolar Cells
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Myoepithelial Cells
Developmental Lineage of Mammary Stem Cells
Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Developmental Lineage of Pancreatic Acinar Cells
Developmental Lineage of Pancreatic Ductal Cells
Developmental Lineages of the Mammary Gland
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Diseases associated with N-glycosylation of proteins
Diseases associated with O-glycosylation of proteins
Diseases associated with glycosaminoglycan metabolism
Diseases associated with glycosylation precursor biosynthesis
Diseases associated with surfactant metabolism
Diseases associated with the TLR signaling cascade
Diseases associated with visual transduction
Diseases of DNA Double-Strand Break Repair
Diseases of branched-chain amino acid catabolism
Diseases of mitochondrial beta oxidation
Diseases of signal transduction by growth factor receptors and second messengers
Drug resistance in ERBB2 TMD/JMD mutants
Drug-induced formation of DNA interstrand crosslinks
E2F-enabled inhibition of pre-replication complex formation
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Enhanced binding of GP1BA variant to VWF multimer:collagen
Enhanced cleavage of VWF variant by ADAMTS13
Enterobacterial factors antagonize host defense
Entry of Influenza Virion into Host Cell via Endocytosis
Epithelial-Mesenchymal Transition (EMT) during gastrulation
Erythropoietin activates Phospholipase C gamma (PLCG)
Evasion by RSV of host interferon responses
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oncogene Induced Senescence Due to p14ARF Defects
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects
Export of Viral Ribonucleoproteins from Nucleus
Expression and translocation of olfactory receptors
Expression of BMAL (ARNTL), CLOCK, and NPAS2
FASTK family proteins regulate processing and stability of mitochondrial RNAs
FOXO-mediated transcription of cell death genes
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of the HIV-1 Early Elongation Complex
Formation of tubulin folding intermediates by CCT/TriC
Fusion and Uncoating of the Influenza Virion
Fusion of the Influenza Virion to the Host Cell Endosome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Gain-of-function MRAS complexes activate RAF signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Glycogen storage disease type 0 (liver GYS2)
Glycogen storage disease type 0 (muscle GYS1)
Glycogen storage disease type Ib (SLC37A4)
H139Hfs13* PPM1K causes a mild variant of MSUD
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IP3 and IP4 transport between cytosol and nucleus
IP6 and IP7 transport between cytosol and nucleus
IPs transport between ER lumen and cytosol
IPs transport between ER lumen and nucleus
IPs transport between cytosol and ER lumen
IPs transport between nucleus and ER lumen
IPs transport between nucleus and cytosol
Impaired BRCA2 translocation to the nucleus
Infection with Mycobacterium tuberculosis
Influenza Viral RNA Transcription and Replication
Inhibition of Host mRNA Processing and RNA Silencing
Inhibition of Signaling by Overexpressed EGFR
InlA-mediated entry of Listeria monocytogenes into host cells
InlB-mediated entry of Listeria monocytogenes into host cell
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Integration of viral DNA into host genomic DNA
Interactions of Rev with host cellular proteins
Interactions of Tat with host cellular proteins
Interactions of Vpr with host cellular proteins
Latent infection - Other responses of Mtb to phagocytosis
Listeria monocytogenes entry into host cells
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Loss of Function of KMT2D in Kabuki Syndrome
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Loss of MECP2 binding ability to 5hmC-DNA
Loss of MECP2 binding ability to 5mC-DNA
Loss of MECP2 binding ability to the NCoR/SMRT complex
Loss of function of MECP2 in Rett syndrome
Loss of function of TP53 in cancer due to loss of tetramerization ability
Loss of phosphorylation of MECP2 at T308
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD
Loss-of-function mutations in DBT cause MSUD2
Loss-of-function mutations in DLD cause MSUD3/DLDD
M-decay: degradation of maternal mRNAs by maternally stored factors
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of genes involved in GABA signaling
MECP2 regulates transcription of neuronal ligands
MPS I - Hurler syndrome (CS/DS degradation)
MPS I - Hurler syndrome (HS-GAG degradation)
MPS II - Hunter syndrome (CS/DS degradation)
MPS II - Hunter syndrome (HS-GAG degradation)
MPS IV - Morquio syndrome B (CS/DS degradation)
MPS IV - Morquio syndrome B (Keratin metabolism)
MPS IX - Natowicz syndrome (CS/DS degradation)
MPS IX - Natowicz syndrome (Hyaluronan metabolism)
MPS VII - Sly syndrome (CS/DS degradation)
MPS VII - Sly syndrome (Hyaluronan metabolism)
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Membrane binding and targetting of GAG proteins
Metabolic disorders of biological oxidation enzymes
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
Microbial modulation of RIPK1-mediated regulated necrosis
Mitochondrial short-chain enoyl-CoA hydratase deficiency 1
NEP/NS2 Interacts with the Cellular Export Machinery
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
NFE2L2 regulates pentose phosphate pathway genes
NFE2L2 regulating ER-stress associated genes
NFE2L2 regulating MDR associated enzymes
NFE2L2 regulating inflammation associated genes
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
Nef mediated downregulation of CD28 cell surface expression
Nef mediated downregulation of MHC class I complex cell surface expression
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Negative regulation of NMDA receptor-mediated neuronal transmission
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Nuclear events stimulated by ALK signaling in cancer
OTC leader sequence variants cause OTC deficiency
OTC main chain variants cause OTC deficiency
PIPs transport between Golgi and plasma membranes
PIPs transport between early and late endosome membranes
PIPs transport between early endosome and Golgi membranes
PIPs transport between late endosome and Golgi membranes
PIPs transport between plasma and early endosome membranes
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
PP2A-mediated dephosphorylation of key metabolic factors
Paradoxical activation of RAF signaling by kinase inactive BRAF
Pausing and recovery of Tat-mediated HIV elongation
Phagocyte cell death caused by cytosolic Mtb
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
Positive Regulation of CDH1 Gene Transcription
Pre-NOTCH Processing in the Endoplasmic Reticulum
Prefoldin mediated transfer of substrate to CCT/TriC
Prevention of phagosomal-lysosomal fusion
Purinergic signaling in leishmaniasis infection
RAS signaling downstream of NF1 loss-of-function variants
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription Termination
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
RPIA deficiency: failed conversion of R5P to RU5P
RPIA deficiency: failed conversion of RU5P to R5P
RUNX1 regulates expression of components of tight junctions
RUNX1 regulates transcription of genes involved in WNT signaling
RUNX2 regulates genes involved in cell migration
RUNX2 regulates genes involved in differentiation of myeloid cells
RUNX3 Regulates Immune Response and Cell Migration
RUNX3 regulates BCL2L11 (BIM) transcription
RUNX3 regulates RUNX1-mediated transcription
Ras activation upon Ca2+ influx through NMDA receptor
Regulation of CDH1 mRNA translation by microRNAs
Regulation of CDH11 mRNA translation by microRNAs
Regulation of CDH19 Expression and Function
Regulation of MITF-M dependent genes involved in invasion
Regulation of MITF-M dependent genes involved in metabolism
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Regulation of activated PAK-2p34 by proteasome mediated degradation
Regulation of cortical dendrite branching
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of gene expression in early pancreatic precursor cells
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Replacement of protamines by nucleosomes in the male pronucleus
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to lapatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to trastuzumab
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Respiratory Syncytial Virus Infection Pathway
Respiratory syncytial virus (RSV) attachment and entry
Respiratory syncytial virus (RSV) genome replication, transcription and translation
Respiratory syncytial virus genome replication
Respiratory syncytial virus genome transcription
Response of EIF2AK1 (HRI) to heme deficiency
Response of EIF2AK4 (GCN2) to amino acid deficiency
Reversible DNA damage induced by alkylating chemotherapeutic drugs
Role of second messengers in netrin-1 signaling
SARS-CoV-1 Genome Replication and Transcription
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-1 modulates host translation machinery
SARS-CoV-1 targets PDZ proteins in cell-cell junction
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-1-mediated effects on programmed cell death
SARS-CoV-2 Genome Replication and Transcription
SARS-CoV-2 activates/modulates innate and adaptive immune responses
SARS-CoV-2 modulates host translation machinery
SARS-CoV-2 targets PDZ proteins in cell-cell junction
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
SHOC2 M1731 mutant abolishes MRAS complex function
SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome
SMAD2/3 Phosphorylation Motif Mutants in Cancer
STAT5 activation downstream of FLT3 ITD mutants
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
Severe congenital neutropenia type 4 (G6PC3)
Signaling by ALK fusions and activated point mutants
Signaling by CSF1 (M-CSF) in myeloid cells
Signaling by CTNNB1 phospho-site mutants
Signaling by FGFR1 amplification mutants
Signaling by FGFR2 amplification mutants
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by PDGFRA extracellular domain mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
Signaling by cytosolic FGFR1 fusion mutants
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Signaling by extracellular domain mutants of KIT
Signaling by high-kinase activity BRAF mutants
Signaling by juxtamembrane domain KIT mutants
Signaling by kinase domain mutants of KIT
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Signaling by moderate kinase activity BRAF mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by plasma membrane FGFR1 fusions
Stimulation of the cell death response by PAK-2p34
Synthesis And Processing Of GAG, GAGPOL Polyproteins
Synthesis of wybutosine at G37 of tRNA(Phe)
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P
TFAP2 (AP-2) family regulates transcription of other transcription factors
TICAM1, RIP1-mediated IKK complex recruitment
TICAM1,TRAF6-dependent induction of TAK1 complex
TLR3-mediated TICAM1-dependent programmed cell death
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
The role of Nef in HIV-1 replication and disease pathogenesis
Tolerance by Mtb to nitric oxide produced by macrophages
Tolerance of reactive oxygen produced by macrophages
Toxicity of botulinum toxin type A (botA)
Toxicity of botulinum toxin type B (botB)
Toxicity of botulinum toxin type C (botC)
Toxicity of botulinum toxin type D (botD)
Toxicity of botulinum toxin type E (botE)
Toxicity of botulinum toxin type F (botF)
Toxicity of botulinum toxin type G (botG)
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Transcriptional regulation of brown and beige adipocyte differentiation
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Transcriptional regulation of pluripotent stem cells
Transcriptional regulation of testis differentiation
Translation of Replicase and Assembly of the Replication Transcription Complex
Translation of respiratory syncytial virus mRNAs
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus
Transport of Ribonucleoproteins into the Host Nucleus
Transport of connexins along the secretory pathway
Truncations of AMER1 destabilize the destruction complex
Variant SLC6A14 may confer susceptibility towards obesity
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)
Viral RNP Complexes in the Host Cell Nucleus
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
Z-decay: degradation of maternal mRNAs by zygotically expressed factors
p75NTR negatively regulates cell cycle via SC1
rRNA modification in the nucleus and cytosol
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis