5-Phosphoribose 1-diphosphate biosynthesis

A tetrasaccharide linker sequence is required for GAG synthesis

ADP signalling through P2Y purinoceptor 1

ADP signalling through P2Y purinoceptor 12

AMPK inhibits chREBP transcriptional activation activity

APC/C-mediated degradation of cell cycle proteins

AUF1 (hnRNP D0) binds and destabilizes mRNA

Acetylcholine Neurotransmitter Release Cycle

Acetylcholine binding and downstream events

Acrosome Reaction and Sperm:Oocyte Membrane Binding

Activation and oligomerization of BAK protein

Activation of ATR in response to replication stress

Activation of BAD and translocation to mitochondria

Activation of BIM and translocation to mitochondria

Activation of BMF and translocation to mitochondria

Activation of Ca-permeable Kainate Receptor

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

Activation of NIMA Kinases NEK9, NEK6, NEK7

Activation of NMDA receptors and postsynaptic events

Activation of NOXA and translocation to mitochondria

Activation of kainate receptors upon glutamate binding

Activation of the AP-1 family of transcription factors

Activation of the TFAP2 (AP-2) family of transcription factors

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the phototransduction cascade

Activation of the pre-replicative complex

Activation, myristolyation of BID and translocation to mitochondria

Adrenaline signalling through Alpha-2 adrenergic receptor

Adrenaline,noradrenaline inhibits insulin secretion

Amino acid transport across the plasma membrane

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Antigen processing: Ubiquitination & Proteasome degradation

Antiviral mechanism by IFN-stimulated genes

Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2

Assembly of active LPL and LIPC lipase complexes

Assembly of collagen fibrils and other multimeric structures

Astrocytic Glutamate-Glutamine Uptake And Metabolism

Axonal growth inhibition (RHOA activation)

B-WICH complex positively regulates rRNA expression

BBSome-mediated cargo-targeting to cilium

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Beta oxidation of butanoyl-CoA to acetyl-CoA

Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA

Beta oxidation of hexanoyl-CoA to butanoyl-CoA

Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA

Beta oxidation of myristoyl-CoA to lauroyl-CoA

Beta oxidation of octanoyl-CoA to hexanoyl-CoA

Beta-oxidation of very long chain fatty acids

Binding and Uptake of Ligands by Scavenger Receptors

Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB

Biosynthesis of DHA-derived sulfido conjugates

Biosynthesis of DPAn-3-derived protectins and resolvins

Biosynthesis of E-series 18(R)-resolvins

Biosynthesis of E-series 18(S)-resolvins

Biosynthesis of aspirin-triggered D-series resolvins

Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives

Biosynthesis of maresin conjugates in tissue regeneration (MCTR)

Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)

Biosynthesis of specialized proresolving mediators (SPMs)

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

CDC6 association with the ORC:origin complex

CDK-mediated phosphorylation and removal of Cdc6

COPI-dependent Golgi-to-ER retrograde traffic

COPI-independent Golgi-to-ER retrograde traffic

CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde

CaMK IV-mediated phosphorylation of CREB

Carboxyterminal post-translational modifications of tubulin

Cargo recognition for clathrin-mediated endocytosis

Cargo trafficking to the periciliary membrane

Caspase activation via Death Receptors in the presence of ligand

Caspase activation via extrinsic apoptotic signalling pathway

Caspase-mediated cleavage of cytoskeletal proteins

Cell death signalling via NRAGE, NRIF and NADE

Cell surface interactions at the vascular wall

ChREBP activates metabolic gene expression

Cholesterol biosynthesis via desmosterol

Cholesterol biosynthesis via lathosterol

Chondroitin sulfate/dermatan sulfate metabolism

Class C/3 (Metabotropic glutamate/pheromone receptors)

Class I MHC mediated antigen processing & presentation

Class I peroxisomal membrane protein import

Classical antibody-mediated complement activation

Cobalamin (Cbl, vitamin B12) transport and metabolism

Collagen biosynthesis and modifying enzymes

Condensation of Prometaphase Chromosomes

Conjugation of phenylacetate with glutamine

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Cross-presentation of particulate exogenous antigens (phagosomes)

Cross-presentation of soluble exogenous antigens (endosomes)

Cyclin A/B1/B2 associated events during G2/M transition

Cyclin A:Cdk2-associated events at S phase entry

Cyclin E associated events during G1/S transition

Cytochrome P450 - arranged by substrate type

Cytosolic sensors of pathogen-associated DNA

Cytosolic sulfonation of small molecules

DDX58/IFIH1-mediated induction of interferon-alpha/beta

DEx/H-box helicases activate type I IFN and inflammatory cytokines production

DNA Damage/Telomere Stress Induced Senescence

Deactivation of the beta-catenin transactivating complex

Dectin-1 mediated noncanonical NF-kB signaling

Degradation of beta-catenin by the destruction complex

Degradation of cysteine and homocysteine

Deposition of new CENPA-containing nucleosomes at the centromere

Detoxification of Reactive Oxygen Species

Disassembly of the destruction complex and recruitment of AXIN to the membrane

Dopamine clearance from the synaptic cleft

Downregulation of SMAD2/3:SMAD4 transcriptional activity

Downstream signaling events of B Cell Receptor (BCR)

Drug-mediated inhibition of CDK4/CDK6 activity

E3 ubiquitin ligases ubiquitinate target proteins

EGFR interacts with phospholipase C-gamma

EGR2 and SOX10-mediated initiation of Schwann cell myelination

Electric Transmission Across Gap Junctions

Energy dependent regulation of mTOR by LKB1-AMPK

Enzymatic degradation of Dopamine by monoamine oxidase

Enzymatic degradation of dopamine by COMT

Epigenetic regulation of gene expression

Erythrocytes take up carbon dioxide and release oxygen

Erythrocytes take up oxygen and release carbon dioxide

Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Estrogen-dependent nuclear events downstream of ESR-membrane signaling

Estrogen-stimulated signaling through PRKCZ

Events associated with phagocytolytic activity of PMN cells

Expression and Processing of Neurotrophins

Extrinsic Pathway of Fibrin Clot Formation

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

FGFR1c and Klotho ligand binding and activation

FLT3 signaling through SRC family kinases

FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

Factors involved in megakaryocyte development and platelet production

Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion

Fcgamma receptor (FCGR) dependent phagocytosis

Formation of ATP by chemiosmotic coupling

Formation of Fibrin Clot (Clotting Cascade)

Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Formation of a pool of free 40S subunits

Formation of the Early Elongation Complex

Formation of the active cofactor, UDP-glucuronate

Formation of the beta-catenin:TCF transactivating complex

Formation of the ternary complex, and subsequently, the 43S complex

Free fatty acids regulate insulin secretion

G beta:gamma signalling through PI3Kgamma

GABA synthesis, release, reuptake and degradation

Gamma carboxylation, hypusine formation and arylsulfatase activation

Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Gastrin-CREB signalling pathway via PKC and MAPK

Generation of second messenger molecules

Global Genome Nucleotide Excision Repair (GG-NER)

Glucagon signaling in metabolic regulation

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Glutamate Neurotransmitter Release Cycle

Glyoxylate metabolism and glycine degradation

Golgi Cisternae Pericentriolar Stack Reorganization

HDR through Homologous Recombination (HRR)

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

HDR through Single Strand Annealing (SSA)

HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

Heparan sulfate/heparin (HS-GAG) metabolism

Highly calcium permeable nicotinic acetylcholine receptors

Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Homologous DNA Pairing and Strand Exchange

Hydroxycarboxylic acid-binding receptors

IL-6-type cytokine receptor ligand interactions

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Inactivation of APC/C via direct inhibition of the APC/C complex

Inactivation, recovery and regulation of the phototransduction cascade

Incretin synthesis, secretion, and inactivation

Inhibition of DNA recombination at telomere

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

Initiation of Nuclear Envelope (NE) Reformation

Insulin effects increased synthesis of Xylulose-5-Phosphate

Interaction With Cumulus Cells And The Zona Pellucida

Interconversion of 2-oxoglutarate and 2-hydroxyglutarate

Interconversion of nucleotide di- and triphosphates

Interleukin-3, Interleukin-5 and GM-CSF signaling

Interleukin-4 and Interleukin-13 signaling

Intra-Golgi and retrograde Golgi-to-ER traffic

Intracellular metabolism of fatty acids regulates insulin secretion

Intracellular signaling by second messengers

Intrinsic Pathway of Fibrin Clot Formation

Ionotropic activity of kainate receptors

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

KSRP (KHSRP) binds and destabilizes mRNA

L13a-mediated translational silencing of Ceruloplasmin expression

Localization of the PINCH-ILK-PARVIN complex to focal adhesions

MAPK targets/ Nuclear events mediated by MAP kinases

Metabolism of Angiotensinogen to Angiotensins

Metabolism of amino acids and derivatives

Metabolism of ingested SeMet, Sec, MeSec into H2Se

Metabolism of nitric oxide: NOS3 activation and regulation

Metabolism of water-soluble vitamins and cofactors

Metal sequestration by antimicrobial proteins

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

Miscellaneous transport and binding events

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Mitochondrial iron-sulfur cluster biogenesis

Molecules associated with elastic fibres

MyD88 cascade initiated on plasma membrane

MyD88 dependent cascade initiated on endosome

MyD88:MAL(TIRAP) cascade initiated on plasma membrane

N-glycan antennae elongation in the medial/trans-Golgi

N-glycan trimming and elongation in the cis-Golgi

N-glycan trimming in the ER and Calnexin/Calreticulin cycle

NOTCH4 Activation and Transmission of Signal to the Nucleus

NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

NRIF signals cell death from the nucleus

Na+/Cl- dependent neurotransmitter transporters

Negative epigenetic regulation of rRNA expression

Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Negative regulation of the PI3K/AKT network

Negative regulators of DDX58/IFIH1 signaling

Neurophilin interactions with VEGF and VEGFR

Neurotransmitter receptors and postsynaptic signal transmission

Neurotransmitter uptake and metabolism In glial cells

Nitric oxide stimulates guanylate cyclase

NoRC negatively regulates rRNA expression

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Norepinephrine Neurotransmitter Release Cycle

Nuclear Events (kinase and transcription factor activation)

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

O-glycosylation of TSR domain-containing proteins

Oligomerization of connexins into connexons

Organic cation/anion/zwitterion transport

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

POLB-Dependent Long Patch Base Excision Repair

PTK6 Regulates Proteins Involved in RNA Processing

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

Phase 1 - inactivation of fast Na+ channels

Phase I - Functionalization of compounds

Phosphate bond hydrolysis by NTPDase proteins

Phosphate bond hydrolysis by NUDT proteins

Plasma lipoprotein assembly, remodeling, and clearance

Platelet activation, signaling and aggregation

Polymerase switching on the C-strand of the telomere

Positive epigenetic regulation of rRNA expression

Post-translational modification: synthesis of GPI-anchored proteins

Post-translational protein phosphorylation

Postmitotic nuclear pore complex (NPC) reformation

Postsynaptic nicotinic acetylcholine receptors

Presynaptic function of Kainate receptors

Presynaptic nicotinic acetylcholine receptors

Processing of Capped Intronless Pre-mRNA

Processing of DNA double-strand break ends

Processive synthesis on the lagging strand

Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2

Protein-protein interactions at synapses

Proton-coupled neutral amino acid transporters

Purine ribonucleoside monophosphate biosynthesis

Pyruvate metabolism and Citric Acid (TCA) cycle

RHO GTPases Activate Rhotekin and Rhophilins

RNA Polymerase I Transcription Initiation

RNA Polymerase II Pre-transcription Events

RNA Polymerase II Transcription Elongation

RNA Polymerase II Transcription Termination

RNA Polymerase III Transcription Initiation

RNA Polymerase III Transcription Initiation From Type 1 Promoter

RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

RUNX1 regulates transcription of genes involved in differentiation of HSCs

RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

RUNX3 regulates YAP1-mediated transcription

Reactions specific to the complex N-glycan synthesis pathway

Reactions specific to the hybrid N-glycan synthesis pathway

Receptor-type tyrosine-protein phosphatases

Recognition and association of DNA glycosylase with site containing an affected purine

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Regulation of APC/C activators between G1/S and early anaphase

Regulation of FOXO transcriptional activity by acetylation

Regulation of HSF1-mediated heat shock response

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Regulation of PLK1 Activity at G2/M Transition

Regulation of RUNX2 expression and activity

Regulation of RUNX3 expression and activity

Regulation of TP53 Activity through Acetylation

Regulation of TP53 Activity through Association with Co-factors

Regulation of TP53 Activity through Methylation

Regulation of TP53 Activity through Phosphorylation

Regulation of TP53 Expression and Degradation

Regulation of actin dynamics for phagocytic cup formation

Regulation of cholesterol biosynthesis by SREBP (SREBF)

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Regulation of gene expression by Hypoxia-inducible Factor

Regulation of gene expression in beta cells

Regulation of innate immune responses to cytosolic DNA

Regulation of lipid metabolism by PPARalpha

Regulation of localization of FOXO transcription factors

Regulation of mRNA stability by proteins that bind AU-rich elements

Regulation of ornithine decarboxylase (ODC)

Regulation of pyruvate dehydrogenase (PDH) complex

Release of apoptotic factors from the mitochondria

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Resolution of D-loop Structures through Holliday Junction Intermediates

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Response to elevated platelet cytosolic Ca2+

Retrograde transport at the Trans-Golgi-Network

Reversal of alkylation damage by DNA dioxygenases

Rhesus glycoproteins mediate ammonium transport.

Role of LAT2/NTAL/LAB on calcium mobilization

SCF(Skp2)-mediated degradation of p27/p21

SCF-beta-TrCP mediated degradation of Emi1

SIRT1 negatively regulates rRNA expression

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs

SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes

SRP-dependent cotranslational protein targeting to membrane

STING mediated induction of host immune responses

Sealing of the nuclear envelope (NE) by ESCRT-III

Senescence-Associated Secretory Phenotype (SASP)

Sensory perception of sweet, bitter, and umami (glutamate) taste

Serotonin clearance from the synaptic cleft

Signal regulatory protein family interactions

Signaling by Non-Receptor Tyrosine Kinases

Signaling by Rho GTPases, Miro GTPases and RHOBTB3

Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

Sodium-coupled sulphate, di- and tri-carboxylate transporters

Switching of origins to a post-replicative state

Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

Synthesis of 12-eicosatetraenoic acid derivatives

Synthesis of 15-eicosatetraenoic acid derivatives

Synthesis of Hepoxilins (HX) and Trioxilins (TrX)

Synthesis of IP2, IP, and Ins in the cytosol

Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of PIPs at the early endosome membrane

Synthesis of PIPs at the late endosome membrane

Synthesis of PIPs at the plasma membrane

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Synthesis of active ubiquitin: roles of E1 and E2 enzymes

Synthesis of bile acids and bile salts via 24-hydroxycholesterol

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Synthesis of glycosylphosphatidylinositol (GPI)

Synthesis of pyrophosphates in the cytosol

Synthesis of substrates in N-glycan biosythesis

Synthesis of very long-chain fatty acyl-CoAs

Synthesis, secretion, and deacylation of Ghrelin

Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

TCF dependent signaling in response to WNT

TFAP2 (AP-2) family regulates transcription of cell cycle factors

TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

TGF-beta receptor signaling activates SMADs

TICAM1-dependent activation of IRF3/IRF7

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

TNFR1-induced NFkappaB signaling pathway

TP53 Regulates Transcription of Caspase Activators and Caspases

TP53 Regulates Transcription of Cell Cycle Genes

TP53 Regulates Transcription of Cell Death Genes

TP53 Regulates Transcription of DNA Repair Genes

TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

TWIK-related alkaline pH activated K+ channel (TALK)

TWIK-related spinal cord K+ channel (TRESK)

TWIK-releated acid-sensitive K+ channel (TASK)

Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)

Tandem pore domain halothane-inhibited K+ channel (THIK)

Telomere C-strand (Lagging Strand) Synthesis

Termination of translesion DNA synthesis

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

The canonical retinoid cycle in rods (twilight vision)

The citric acid (TCA) cycle and respiratory electron transport

The retinoid cycle in cones (daylight vision)

The role of GTSE1 in G2/M progression after G2 checkpoint

Thrombin signalling through proteinase activated receptors (PARs)

Thromboxane signalling through TP receptor

Trafficking and processing of endosomal TLR

Trafficking of myristoylated proteins to the cilium

Transcription from mitochondrial promoters

Transcriptional activation of cell cycle inhibitor p21

Transcriptional activation of mitochondrial biogenesis

Transcriptional activation of p53 responsive genes

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Transport of bile salts and organic acids, metal ions and amine compounds

Transport of connexons to the plasma membrane

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus

Transport of glycerol from adipocytes to the liver by Aquaporins

Transport of inorganic cations/anions and amino acids/oligopeptides

Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Transport of vitamins, nucleosides, and related molecules

Transport to the Golgi and subsequent modification

Ubiquitin-dependent degradation of Cyclin D

Uptake of dietary cobalamins into enterocytes

VEGF binds to VEGFR leading to receptor dimerization

Vasopressin regulates renal water homeostasis via Aquaporins

Vitamins B6 activation to pyridoxal phosphate

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

YAP1- and WWTR1 (TAZ)-stimulated gene expression

ZBP1(DAI) mediated induction of type I IFNs

Zinc efflux and compartmentalization by the SLC30 family

Zinc influx into cells by the SLC39 gene family

activated TAK1 mediates p38 MAPK activation

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

mitochondrial fatty acid beta-oxidation of saturated fatty acids

mitochondrial fatty acid beta-oxidation of unsaturated fatty acids

p53-Dependent G1/S DNA damage checkpoint

AKT phosphorylates targets in the cytosol

AKT phosphorylates targets in the nucleus

Acetylcholine regulates insulin secretion

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

Activation of G protein gated Potassium channels

Anchoring of the basal body to the plasma membrane

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Apoptotic cleavage of cell adhesion proteins

Assembly and cell surface presentation of NMDA receptors

Assembly of the ORC complex at the origin of replication

Association of TriC/CCT with target proteins during biosynthesis

Autodegradation of the E3 ubiquitin ligase COP1

Beta oxidation of palmitoyl-CoA to myristoyl-CoA

CLEC7A (Dectin-1) induces NFAT activation

CREB1 phosphorylation through the activation of Adenylate Cyclase

Caspase activation via Dependence Receptors in the absence of ligand

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

Displacement of DNA glycosylase by APEX1

Downregulation of TGF-beta receptor signaling

Drug-mediated inhibition of ERBB2 signaling

Drug-mediated inhibition of MET activation

E2F mediated regulation of DNA replication

EML4 and NUDC in mitotic spindle formation

Electron transport from NADPH to Ferredoxin

Endosomal Sorting Complex Required For Transport (ESCRT)

Establishment of Sister Chromatid Cohesion

FOXO-mediated transcription of cell cycle genes

Formation of RNA Pol II elongation complex

Formation of TC-NER Pre-Incision Complex

Formation of editosomes by ADAR proteins

GRB2:SOS provides linkage to MAPK signaling for Integrins

GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

GTP hydrolysis and joining of the 60S ribosomal subunit

Gap-filling DNA repair synthesis and ligation in GG-NER

Gap-filling DNA repair synthesis and ligation in TC-NER

Glutamate binding, activation of AMPA receptors and synaptic plasticity

Highly sodium permeable postsynaptic acetylcholine nicotinic receptors

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Inhibition of replication initiation of damaged DNA by RB1/E2F1

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Ion influx/efflux at host-pathogen interface

LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production

Major pathway of rRNA processing in the nucleolus and cytosol

Negative feedback regulation of MAPK pathway

PCNA-Dependent Long Patch Base Excision Repair

PI and PC transport between ER and Golgi membranes

PKA-mediated phosphorylation of key metabolic factors

Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes

Post-transcriptional silencing by small RNAs

Presynaptic depolarization and calcium channel opening

Presynaptic phase of homologous DNA pairing and strand exchange

Processing of Capped Intron-Containing Pre-mRNA

Proton-coupled monocarboxylate transport

RNA Pol II CTD phosphorylation and interaction with CE

RNA Polymerase II Transcription Initiation

RNA Polymerase II Transcription Initiation And Promoter Clearance

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

RNA polymerase II transcribes snRNA genes

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

RUNX1 regulates transcription of genes involved in BCR signaling

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

RUNX1 regulates transcription of genes involved in interleukin signaling

Recognition of DNA damage by PCNA-containing replication complex

Regulation of Glucokinase by Glucokinase Regulatory Protein

Regulation of PTEN stability and activity

Regulation of RUNX1 Expression and Activity

Regulation of commissural axon pathfinding by SLIT and ROBO

Regulation of expression of SLITs and ROBOs

Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Ribosomal scanning and start codon recognition

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

STAT3 nuclear events downstream of ALK signaling

SUMO E3 ligases SUMOylate target proteins

SUMO is transferred from E1 to E2 (UBE2I, UBC9)

SUMOylation of DNA damage response and repair proteins

SUMOylation of chromatin organization proteins

Sema4D induced cell migration and growth-cone collapse

Sema4D mediated inhibition of cell attachment and migration

Serotonin Neurotransmitter Release Cycle

Small interfering RNA (siRNA) biogenesis

Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Transcriptional regulation by small RNAs

Transport of Mature Transcript to Cytoplasm

Transport of Mature mRNA Derived from an Intronless Transcript

Transport of Mature mRNA derived from an Intron-Containing Transcript

Transport of Mature mRNAs Derived from Intronless Transcripts

Transport of the SLBP Dependant Mature mRNA

Transport of the SLBP independent Mature mRNA

Unblocking of NMDA receptors, glutamate binding and activation

rRNA processing in the nucleus and cytosol

APC/C:Cdc20 mediated degradation of Cyclin B

APC/C:Cdc20 mediated degradation of Securin

APC/C:Cdc20 mediated degradation of mitotic proteins

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint

APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

ARL13B-mediated ciliary trafficking of INPP5E

Abasic sugar-phosphate removal via the single-nucleotide replacement pathway

Activated NTRK2 signals through FRS2 and FRS3

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

Activation of Na-permeable kainate receptors

Activation, translocation and oligomerization of BAX

Advanced glycosylation endproduct receptor signaling

Alpha-protein kinase 1 signaling pathway

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

Amplification of signal from the kinetochores

Biosynthesis of DPAn-3-derived 13-series resolvins

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Cytochrome c-mediated apoptotic response

Ficolins bind to repetitive carbohydrate structures on the target cell surface

Formyl peptide receptors bind formyl peptides and many other ligands

G beta:gamma signalling through PLC beta

GLI3 is processed to GLI3R by the proteasome

Gamma-carboxylation of protein precursors

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

IRAK2 mediated activation of TAK1 complex

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Inhibition of TSC complex formation by PKB

Loss of proteins required for interphase microtubule organization from the centrosome

Metabolism of ingested MeSeO2H into MeSeH

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Orexin and neuropeptides FF and QRFP bind to their respective receptors

Phosphorylation of CD3 and TCR zeta chains

Processive synthesis on the C-strand of the telomere

RNA Polymerase I Transcription Termination

RNA Polymerase III Transcription Initiation From Type 2 Promoter

RNA Polymerase III Transcription Initiation From Type 3 Promoter

RUNX2 regulates osteoblast differentiation

Recognition and association of DNA glycosylase with site containing an affected pyrimidine

Recruitment of NuMA to mitotic centrosomes

Recruitment of mitotic centrosome proteins and complexes

Regulation of HMOX1 expression and activity

Regulation of MECP2 expression and activity

Release of Hh-Np from the secreting cell

Removal of the Flap Intermediate from the C-strand

Resolution of AP sites via the single-nucleotide replacement pathway

Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

TAK1-dependent IKK and NF-kappa-B activation

TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

TRAF6-mediated induction of TAK1 complex within TLR4 complex

Trafficking of GluR2-containing AMPA receptors

Transcriptional regulation of granulopoiesis

Translation initiation complex formation

Translocation of ZAP-70 to Immunological synapse

Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

p53-Independent G1/S DNA damage checkpoint

Activated NOTCH1 Transmits Signal to the Nucleus

Activation of caspases through apoptosome-mediated cleavage

Prostacyclin signalling through prostacyclin receptor
RUNX1 regulates estrogen receptor mediated transcription
SUMOylation of ubiquitinylation proteins
TP53 Regulates Transcription of Death Receptors and Ligands
p130Cas linkage to MAPK signaling for integrins
Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'
Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'
Activation of RAC1:GTP by FZ:DSH complex
Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY
Adaptor protein complex binds to TL receptor at the plasma membrane
Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'
Catalytic processing of the nuclear factor, REL
DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
Degradation of NF-kappa-B inhibitor, CACT
Dephosphorylation by PTP61F phosphatases
Formation and asymmetric localisation of transmembrane complexes
Formation and transport of the N-HH ligand
Formation of the PGN:PGRP-LC/LE receptor 'signalling complex'
Formation of the activated STAT92E dimer and transport to the nucleus
Formation of the activated receptor complex
Formation of the cytosolic BSK 'scaffolding complex'
Formation of the nuclear AP-1 transcription factor 'scaffolding complex'
Formation of the trans-membrane 'signalling complex'
Homo-/heterophilic binding of transmembrane components
N-HH ligand bound to PTC receptor complex
N-HH ligand not bound to PTC receptor complex
Negative feedback loop regulates asymmetric localisation
PLL kinase binds to TUB in the TL receptor 'signalling complex'
Peptidoglycan bound PGRP-LC/LE oligomerises
Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE
Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
Phosphorylated REL is cleaved by and dissociates from DREDD
Phosphorylation-dependent inhibition of YKI
Phosphorylation-independent inhibition of YKI
REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol
Transcription activation by CLK:CYC and repression by VRI
Transcription repression by PER and activation by PDP1
Transcriptional activtion and repression of REL-68 target genes
Transcriptional activtion by AP-1 transcription factor
Transcriptional activtion by phosphorylated DL/DIF dimer
Transcriptional regulation of white adipocyte differentiation
Transcriptional repression by nuclear factors
Ubiquitination and degradation of phosphorylated ARM
Ubiquitination and proteolysis of phosphorylated CI
ATM mediated phosphorylation of repair proteins
ATM mediated response to DNA double-strand break
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation
Activated TAK1 mediates p38 MAP kinase phosphorylation
Anaphylatoxins initiate inflammatory responses
Assembly of telomerase and telomere extension
Base Excision Repair, AP site formation by depyrimidination
Caspase-8 and -10 mediated induction of NF-kB
Chk1-controlled and DNA-damage induced centrosome duplication
Creation of alternative pathway C3 convertase
DNA damage recognition in global genomic repair
Formation of membrane attack complex (MAC)
Formation of membrane-bound convertase C3
Homologous recombination repair (HRR) of replication-independent double-strand breaks
Homologous recombination repair of replication-dependent double-strand breaks
IKK complex recruitment mediated by RIP1
IKK related kinases bound to dsRNA:TLR3:TICAM1 activate IRF3
Lectin-mediated initiation of complement cascade
MAP3K8 (TPL2)-dependent MAPK1/3 activation
MyD88-dependent cascade initiated on endosome membrane
MyD88:TIRAP-dependent cascade initiated on plasma membrane
NFkB and MAPK activation mediated by TRAF6
NFkB activation mediated by RIP1 complexed with activated TLR3
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH2 intracellular domain regulates transcription
NOTCH3 Activation and Transmission of Signal to the Nucleus
Pyrimidine metabolism: de novo synthesis of UMP
RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases
RLR (RIG-like receptor) mediated induction of IFN alpha/beta
Recruitment of repair and signaling proteins to double-strand breaks
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
TRAF6 mediated induction of proinflammatory cytokines
Transfer of LPS from LBP carrier to CD14
Translesion synthesis by DNA polymerases bypassing lesion on DNA template
Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK
Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1
ADORA2B mediated anti-inflammatory cytokines production
ALKBH2 mediated reversal of alkylation damage
ALKBH3 mediated reversal of alkylation damage
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
APOBEC3G mediated resistance to HIV-1 infection
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
AXIN missense mutants destabilize the destruction complex
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
Aberrant regulation of mitotic cell cycle due to RB1 defects
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
Abortive elongation of HIV-1 transcript in the absence of Tat
Acetylcholine inhibits contraction of outer hair cells
Activation of HOX genes during differentiation
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Activation of PUMA and translocation to mitochondria
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activation of gene expression by SREBF (SREBP)
Alkylating DNA damage induced by chemotherapeutic drugs
Alternative Lengthening of Telomeres (ALT)
Anti-inflammatory response favouring Leishmania parasite infection
Antimicrobial action and antimicrobial resistance in Mtb
Assembly of Viral Components at the Budding Site
Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)
Autointegration results in viral DNA circles
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Binding of TCF/LEF:CTNNB1 to target gene promoters
Biosynthesis of A2E, implicated in retinal degradation
CD163 mediating an anti-inflammatory response
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
Cell recruitment (pro-inflammatory response)
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Constitutive Signaling by AKT1 E17K in Cancer
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Constitutive Signaling by Overexpressed ERBB2
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Defective ABCB4 causes PFIC3, ICP3 and GBD1
Defective ABCC8 can cause hypo- and hyper-glycemias
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome
Defective ABCG8 causes GBD4 and sitosterolemia
Defective ADA disrupts (deoxy)adenosine deamination
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective B4GALT7 causes EDS, progeroid type
Defective BTD causes biotidinase deficiency
Defective Base Excision Repair Associated with MUTYH
Defective Base Excision Repair Associated with NEIL1
Defective Base Excision Repair Associated with NEIL3
Defective Base Excision Repair Associated with NTHL1
Defective Base Excision Repair Associated with OGG1
Defective CHST14 causes EDS, musculocontractural type
Defective CP causes aceruloplasminemia (ACERULOP)
Defective CYP11B2 causes CMO-1 deficiency
Defective DNA double strand break response due to BARD1 loss of function
Defective DNA double strand break response due to BRCA1 loss of function
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective F8 accelerates dissociation of the A2 domain
Defective F8 binding to the cell membrane
Defective F8 binding to von Willebrand factor
Defective F9 variant does not activate FX
Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)
Defective GGT1 in aflatoxin detoxification causes GLUTH
Defective GNE causes sialuria, NK and IBM2
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Defective HK1 causes hexokinase deficiency (HK deficiency)
Defective HLCS causes multiple carboxylase deficiency
Defective HPRT1 disrupts guanine and hypoxanthine salvage
Defective Inhibition of DNA Recombination at Telomere
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
Defective Intrinsic Pathway for Apoptosis
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Defective LARGE causes MDDGA6 and MDDGB6
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH3
Defective Mismatch Repair Associated With MSH6
Defective Mismatch Repair Associated With PMS2
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2
Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)
Defective RIPK1-mediated regulated necrosis
Defective SERPING1 causes hereditary angioedema
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)
Defective SLC12A1 causes Bartter syndrome 1 (BS1)
Defective SLC12A3 causes Gitelman syndrome (GS)
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
Defective SLC17A5 causes Salla disease (SD) and ISSD
Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Defective SLC1A3 causes episodic ataxia 6 (EA6)
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)
Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)
Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)
Defective SLC26A2 causes chondrodysplasias
Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
Defective SLC26A4 causes Pendred syndrome (PDS)
Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)
Defective SLC2A10 causes arterial tortuosity syndrome (ATS)
Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)
Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)
Defective SLC33A1 causes spastic paraplegia 42 (SPG42)
Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)
Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)
Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)
Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)
Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)
Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)
Defective SLC3A1 causes cystinuria (CSNU)
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)
Defective SLC5A2 causes renal glucosuria (GLYS1)
Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)
Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria
Defective SLC6A19 causes Hartnup disorder (HND)
Defective SLC6A2 causes orthostatic intolerance (OI)
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)
Defective SLC7A7 causes lysinuric protein intolerance (LPI)
Defective SLC7A9 causes cystinuria (CSNU)
Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH)
Defective SLC9A9 causes autism 16 (AUTS16)
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
Defective SRD5A3 causes SRD5A3-CDG, KHRZ
Defective ST3GAL3 causes MCT12 and EIEE15
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Defective UGT1A1 causes hyperbilirubinemia
Defective UGT1A4 causes hyperbilirubinemia
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective cofactor function of FVIIIa variant
Defective factor IX causes thrombophilia
Defective factor VIII causes hemophilia A
Defective factor XII causes hereditary angioedema
Defective homologous recombination repair (HRR) due to BRCA2 loss of function
Defective pro-SFTPB causes SMDP1 and RDS
Defective pro-SFTPC causes SMDP2 and RDS
Defective translocation of RB1 mutants to the nucleus
Defects in vitamin and cofactor metabolism
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
Deletions in the AMER1 gene destabilize the destruction complex
Deletions in the AXIN1 gene destabilize the destruction complex
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Diseases associated with N-glycosylation of proteins
Diseases associated with O-glycosylation of proteins
Diseases associated with glycosaminoglycan metabolism
Diseases associated with glycosylation precursor biosynthesis
Diseases associated with surfactant metabolism
Diseases associated with the TLR signaling cascade
Diseases associated with visual transduction
Diseases of DNA Double-Strand Break Repair
Diseases of mitochondrial beta oxidation
Diseases of signal transduction by growth factor receptors and second messengers
Drug resistance in ERBB2 TMD/JMD mutants
Drug-induced formation of DNA interstrand crosslinks
E2F-enabled inhibition of pre-replication complex formation
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Entry of Influenza Virion into Host Cell via Endocytosis
Erythropoietin activates Phospholipase C gamma (PLCG)
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oncogene Induced Senescence Due to p14ARF Defects
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects
Export of Viral Ribonucleoproteins from Nucleus
Expression and translocation of olfactory receptors
FOXO-mediated transcription of cell death genes
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of the HIV-1 Early Elongation Complex
Formation of tubulin folding intermediates by CCT/TriC
Fusion and Uncoating of the Influenza Virion
Fusion of the Influenza Virion to the Host Cell Endosome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Gain-of-function MRAS complexes activate RAF signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Glycogen storage disease type 0 (liver GYS2)
Glycogen storage disease type 0 (muscle GYS1)
Glycogen storage disease type Ib (SLC37A4)
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IP3 and IP4 transport between cytosol and nucleus
IP6 and IP7 transport between cytosol and nucleus
IPs transport between ER lumen and cytosol
IPs transport between ER lumen and nucleus
IPs transport between cytosol and ER lumen
IPs transport between nucleus and ER lumen
IPs transport between nucleus and cytosol
Impaired BRCA2 translocation to the nucleus
Infection with Mycobacterium tuberculosis
Influenza Viral RNA Transcription and Replication
Inhibition of Host mRNA Processing and RNA Silencing
Inhibition of Signaling by Overexpressed EGFR
InlA-mediated entry of Listeria monocytogenes into host cells
InlB-mediated entry of Listeria monocytogenes into host cell
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Integration of viral DNA into host genomic DNA
Interactions of Rev with host cellular proteins
Interactions of Tat with host cellular proteins
Interactions of Vpr with host cellular proteins
Latent infection - Other responses of Mtb to phagocytosis
Listeria monocytogenes entry into host cells
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Loss of MECP2 binding ability to 5hmC-DNA
Loss of MECP2 binding ability to 5mC-DNA
Loss of MECP2 binding ability to the NCoR/SMRT complex
Loss of function of MECP2 in Rett syndrome
Loss of function of TP53 in cancer due to loss of tetramerization ability
Loss of phosphorylation of MECP2 at T308
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of genes involved in GABA signaling
MECP2 regulates transcription of neuronal ligands
Membrane binding and targetting of GAG proteins
Metabolic disorders of biological oxidation enzymes
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
Microbial modulation of RIPK1-mediated regulated necrosis
NEP/NS2 Interacts with the Cellular Export Machinery
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
NR1D1 (REV-ERBA) represses gene expression
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
Nef mediated downregulation of CD28 cell surface expression
Nef mediated downregulation of MHC class I complex cell surface expression
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Negative regulation of NMDA receptor-mediated neuronal transmission
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Nuclear events stimulated by ALK signaling in cancer
PIPs transport between Golgi and plasma membranes
PIPs transport between early and late endosome membranes
PIPs transport between early endosome and Golgi membranes
PIPs transport between late endosome and Golgi membranes
PIPs transport between plasma and early endosome membranes
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
PP2A-mediated dephosphorylation of key metabolic factors
Paradoxical activation of RAF signaling by kinase inactive BRAF
Pausing and recovery of Tat-mediated HIV elongation
Phagocyte cell death caused by cytosolic Mtb
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Pre-NOTCH Processing in the Endoplasmic Reticulum
Prefoldin mediated transfer of substrate to CCT/TriC
Prevention of phagosomal-lysosomal fusion
Purinergic signaling in leishmaniasis infection
RAS signaling downstream of NF1 loss-of-function variants
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription Termination
RPIA deficiency: failed conversion of R5P to RU5P
RPIA deficiency: failed conversion of RU5P to R5P
RUNX1 regulates expression of components of tight junctions
RUNX1 regulates transcription of genes involved in WNT signaling
RUNX2 regulates genes involved in cell migration
RUNX2 regulates genes involved in differentiation of myeloid cells
RUNX3 Regulates Immune Response and Cell Migration
RUNX3 regulates BCL2L11 (BIM) transcription
RUNX3 regulates RUNX1-mediated transcription
Ras activation upon Ca2+ influx through NMDA receptor
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Regulation of cortical dendrite branching
Regulation of gene expression in early pancreatic precursor cells
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to lapatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to trastuzumab
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Response of EIF2AK1 (HRI) to heme deficiency
Response of EIF2AK4 (GCN2) to amino acid deficiency
Reversible DNA damage induced by alkylating chemotherapeutic drugs
Role of second messengers in netrin-1 signaling
SARS-CoV-1 Genome Replication and Transcription
SARS-CoV-2 Genome Replication and Transcription
SARS-CoV-2 activates/modulates innate and adaptive immune responses
SARS-CoV-2 modulates host translation machinery
SARS-CoV-2 targets PDZ proteins in cell-cell junction
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
SHOC2 M1731 mutant abolishes MRAS complex function
SMAD2/3 Phosphorylation Motif Mutants in Cancer
STAT5 activation downstream of FLT3 ITD mutants
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
Severe congenital neutropenia type 4 (G6PC3)
Signaling by ALK fusions and activated point mutants
Signaling by CTNNB1 phospho-site mutants
Signaling by FGFR1 amplification mutants
Signaling by FGFR2 amplification mutants
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by PDGFRA extracellular domain mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
Signaling by cytosolic FGFR1 fusion mutants
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Signaling by extracellular domain mutants of KIT
Signaling by high-kinase activity BRAF mutants
Signaling by juxtamembrane domain KIT mutants
Signaling by kinase domain mutants of KIT
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Signaling by moderate kinase activity BRAF mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by plasma membrane FGFR1 fusions
Stimulation of the cell death response by PAK-2p34
Synthesis And Processing Of GAG, GAGPOL Polyproteins
Synthesis of wybutosine at G37 of tRNA(Phe)
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P
TFAP2 (AP-2) family regulates transcription of other transcription factors
TICAM1, RIP1-mediated IKK complex recruitment
TICAM1,TRAF6-dependent induction of TAK1 complex
TLR3-mediated TICAM1-dependent programmed cell death
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
The role of Nef in HIV-1 replication and disease pathogenesis
Tolerance by Mtb to nitric oxide produced by macrophages
Tolerance of reactive oxygen produced by macrophages
Toxicity of botulinum toxin type A (botA)
Toxicity of botulinum toxin type B (botB)
Toxicity of botulinum toxin type C (botC)
Toxicity of botulinum toxin type D (botD)
Toxicity of botulinum toxin type E (botE)
Toxicity of botulinum toxin type F (botF)
Toxicity of botulinum toxin type G (botG)
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Transcriptional regulation of pluripotent stem cells
Transcriptional regulation of testis differentiation
Translation of Replicase and Assembly of the Replication Transcription Complex
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus
Transport of Ribonucleoproteins into the Host Nucleus
Transport of connexins along the secretory pathway
Truncations of AMER1 destabilize the destruction complex
Variant SLC6A14 may confer susceptibility towards obesity
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)
Viral RNP Complexes in the Host Cell Nucleus
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
p75NTR negatively regulates cell cycle via SC1
rRNA modification in the nucleus and cytosol
tRNA modification in the nucleus and cytosol
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis
Mycobacterium tuberculosis biological processes