aggregator_knowledge_source: infores:medic
biolink_version: 4.4.6
build_date: '2026-11-01'
description: Drug-disease indications, contraindications, adverse events and research
  associations built from government regulatory sources.
edges:
  by_category:
    biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation: 42283
    biolink:ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation: 82288
  by_knowledge_level:
    knowledge_assertion: 124562
    observation: 9
  by_predicate:
    biolink:contraindicated_in: 41273
    biolink:diagnoses: 1010
    biolink:in_clinical_trials_for: 8
    biolink:preventative_for_condition: 12847
    biolink:studied_to_treat: 1
    biolink:treats: 69432
  by_primary_knowledge_source:
    infores:cdsco: 1322
    infores:ema: 3489
    infores:fda-dailymed: 117259
    infores:pmda: 2492
    infores:pubmed: 9
  by_reliability:
    HIGH: 53050
    LOW: 48968
    MEDIUM: 22553
  total: 124571
extraction_agents:
- agent_name: anthropic/claude-haiku-4-5-20251001
  agent_version: claude-haiku-4-5-20251001
  assertions: 124572
  method: LLM
  tool: medic-extractor
  tool_version: '1'
grounding_ontologies:
  chebi:
    url: http://purl.obolibrary.org/obo/chebi/253/chebi.json
    version: '253'
  dron:
    url: http://purl.obolibrary.org/obo/dron/releases/2026-06-04/dron.json
    version: '2026-06-04'
  hp:
    url: http://purl.obolibrary.org/obo/hp/releases/2026-06-23/hp.json
    version: '2026-06-23'
  mondo:
    url: http://purl.obolibrary.org/obo/mondo/releases/2026-07-06/mondo.json
    version: '2026-07-06'
license:
  attribution_notice: "Contains data from the European Medicines Agency (\xA9 EMA),\
    \ the Pharmaceuticals and Medical Devices Agency of Japan (PMDA, https://www.pmda.go.jp),\
    \ the Central Drugs Standard Control Organisation of India (CDSCO), EveryCure\
    \ (drug-list and disease-list, CC BY 4.0) and the Mondo Disease Ontology (CC BY\
    \ 4.0). Data has been edited: source records were parsed, translated, normalised,\
    \ and mapped to ontology identifiers by the MeDIC pipeline. None of these bodies\
    \ endorses this derived work."
  medic_grant: none
  note: Redistributing this graph takes on the obligations of every contributing source.
    EMA and PMDA both require attribution; PMDA additionally requires that edited
    content be marked as edited.
  terms: https://github.com/monarch-initiative/medic/blob/main/LICENSING.md
medic_version: 2.0.0
name: MeDIC
nodes:
  by_category:
    biolink:ChemicalEntity: 458
    biolink:Disease: 24825
    biolink:Drug: 4399
    biolink:NamedThing: 44
    biolink:PhenotypicFeature: 555
  stubs: 2658
  total: 30281
source_explanations:
- assertions: 1322
  description: CDSCO-approved indication from India primary source PDF
  primary_knowledge_source: infores:cdsco
- assertions: 532
  description: "EMA contraindication from EPAR Product Information SmPC \xA74.3"
  primary_knowledge_source: infores:ema
- assertions: 2957
  description: EMA-approved indication from EMA medicines spreadsheet (primary source)
  primary_knowledge_source: infores:ema
- assertions: 40724
  description: FDA contraindication from DailyMed structured product label
  primary_knowledge_source: infores:fda-dailymed
- assertions: 76545
  description: FDA-approved indication from DailyMed structured product label
  primary_knowledge_source: infores:fda-dailymed
- assertions: 17
  description: PMDA contraindication from per-product review report
  primary_knowledge_source: infores:pmda
- assertions: 934
  description: PMDA-approved indication; per-product review report
  primary_knowledge_source: infores:pmda
- assertions: 1541
  description: PMDA-approved indication; review report not yet linked (search URL
    fallback)
  primary_knowledge_source: infores:pmda